Abstract
Theragnostic nanoparticles (NPs) contain diagnostic and therapeutic functions in one integrated system, enabling diagnosis, therapy, and monitoring of therapeutic response at the same time. For diagnostic function, theragnostic NPs require the inclusion of noninvasive imaging modalities. Among them, optical imaging has various advantages including sensitivity, real-time and convenient use, and non-ionization safety, which make it the leading technique for theragnostic NPs. For therapeutic function, theragnostic NPs have been applied to chemotherapy, photodynamic therapy, siRNA therapy and photothermal therapy. In this review, we present a recent progress reported in the development and applications of theragnostic NPs for cancer therapy. More specifically, we will focus on theragnostic NPs related with optical imaging, highlighting promising strategies based on optical imaging techniques.
| Original language | English |
|---|---|
| Pages (from-to) | 1447-1458 |
| Number of pages | 12 |
| Journal | Advanced Drug Delivery Reviews |
| Volume | 64 |
| Issue number | 13 |
| DOIs | |
| State | Published - Oct 2012 |
Bibliographical note
Funding Information:This work is supported by the M.D.-Ph.D. Program ( 2010-0019863 , 2010-0019864 ), the Global Research Laboratory Project of MEST , and the Intramural Research Program (Theragnosis) of KIST .
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Cancer
- Chemotherapy
- Molecular imaging
- Nanomedicine
- Optical imaging
- Personalized medicine
- Photodynamic therapy
- Photothermal therapy
- SiRNA therapy
- Theragnosis
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