Two cases of concurrent development of essential thrombocythemia with chronic lymphocytic leukemia, one related to clonal B-cell lymphocytosis, tested by array comparative genomic hybridization

Hyunjung Kim, Woori Jang, Soyoung Shin, Joonhong Park, Myungshin Kim, Yonggoo Kim, Kyungja Han, Gun Dong Lee, Heusung Won, Young Jun Yang

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7 Scopus citations

Abstract

We present two cases of concurrent development of essential thrombocythemia (ET) with chronic lymphocytic leukemia (CLL) and one related to clonal B-cell lymphocytosis (CBL). Both patients were referred for lymphocytosis and thrombocytosis. A bone marrow biopsy revealed infiltration of small, mature lymphocytes and megakaryocytic hyperplasia. Flow cytometric immunophenotyping and immunoglobulin (IG) gene clonality tests revealed clonal B lymphocytes. Both patients were positive for the JAK2 V617F mutation in whole bone marrow aspirate. The JAK2 V617F mutation was present in isolated B lymphocytes of patient 1, but not patient 2. Cytogenetics were normal in both patients. An array comparative genomic hybridization (CGH) analyses of B cells revealed a gain of 4q28.3, which is reported in non-Hodgkin’s lymphoma, in patient 1, and deletion 22q11.22, which is associated with CLL, and a gain of Xp22.31 in patient 2. In both patients, B cells showed no myeloproliferative neoplasm (MPN)-specific genetic abnormalities. These results suggest that different oncogenic mechanisms in each cell lineage may underlie the concurrent development of ET and CLL (or CBL). Array CGH may be helpful in identifying the pathogenic mechanism in cases of concurrent development of lymphoid neoplasm and MPN.

Original languageEnglish
Pages (from-to)612-619
Number of pages8
JournalInternational Journal of Hematology
Volume101
Issue number6
DOIs
StatePublished - 10 Dec 2015

Bibliographical note

Publisher Copyright:
© 2014, The Japanese Society of Hematology.

Keywords

  • CGH
  • Chronic lymphocytic leukemia
  • Clonal B-cell lymphocytosis
  • Essential thrombocythemia
  • JAK2 V617F

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