TY - JOUR
T1 - Type II collagen autoimmunity in a mouse model of human rheumatoid arthritis
AU - Cho, Young Gyu
AU - Cho, Mi La
AU - Min, So Youn
AU - Kim, Ho Youn
PY - 2007/11
Y1 - 2007/11
N2 - Type II collagen (CII) is expressed exclusively in the joint articular. Although the relationship between anti-CII immunity and human rheumatoid arthritis (RA) has been studied for a long time, definitive conclusions have not been reached. CII, as an autoantigen, has been studied extensively in small animal models, such as mice, and the collagen-induced arthritis (CIA) model has increased our understanding of the pathogenesis of human RA. In the present report, we summarize the available information on anti-CII immunity and discuss recent updates regarding pathogenesis in the CIA model, including the role of Th17 cells.
AB - Type II collagen (CII) is expressed exclusively in the joint articular. Although the relationship between anti-CII immunity and human rheumatoid arthritis (RA) has been studied for a long time, definitive conclusions have not been reached. CII, as an autoantigen, has been studied extensively in small animal models, such as mice, and the collagen-induced arthritis (CIA) model has increased our understanding of the pathogenesis of human RA. In the present report, we summarize the available information on anti-CII immunity and discuss recent updates regarding pathogenesis in the CIA model, including the role of Th17 cells.
KW - Collagen-induced arthritis (CIA)
KW - IL-17
KW - Rheumatoid arthritis (RA)
KW - Toll-like receptor (TLR)
UR - http://www.scopus.com/inward/record.url?scp=35548929833&partnerID=8YFLogxK
U2 - 10.1016/j.autrev.2007.08.001
DO - 10.1016/j.autrev.2007.08.001
M3 - Review article
C2 - 17967728
AN - SCOPUS:35548929833
SN - 1568-9972
VL - 7
SP - 65
EP - 70
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
IS - 1
ER -