Up-regulated CNTF plays a protective role for retrograde degeneration in the axotomized rat retina

Won Kyu Ju; Keun Young Kim; Mun Yong Lee; Hans Dieter Hofmann; Matthias Kirsch; Jung Ho Cha; Su Ja Oh; Myung Hoon Chun

doi:10.1097/00001756-200011270-00057

Up-regulated CNTF plays a protective role for retrograde degeneration in the axotomized rat retina

Won Kyu Ju
, Keun Young Kim
, Mun Yong Lee
, Hans Dieter Hofmann
, Matthias Kirsch
, Jung Ho Cha
, Su Ja Oh
, Myung Hoon Chun

Department of Anatomy

The Catholic University of Korea
University of Freiburg

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Using reverse transcription-polymerase chain reaction and in situ hybridization, we investigated the expression and cellular localization of ciliary neurotrophic factor receptor α (CNTFRα) in the rat retina following optic nerve transection (ONT). Following ONT, a signal for CNTFRα mRNA appeared in a layer-specific and time-dependent manner. In the ganglion cell layer, the signal showed a peak value I day after ONT, and then gradually decreased. In the inner nuclear layer the signal reached a peak value at 14 days of about 500% of control level, but then decreased at 4 weeks. Our findings suggest that CNTF might play a protective role for the retrograde degeneration of retinal cells induced by ganglion cell death in the rat retina following ONT. (C) 2000 Lippincott Williams and Wilkins.

Original language	English
Pages (from-to)	3893-3896
Number of pages	4
Journal	NeuroReport
Volume	11
Issue number	17
DOIs	https://doi.org/10.1097/00001756-200011270-00057
State	Published - 27 Nov 2000

Keywords

Ciliary neurotrophic factor receptor α
In situ hybridization
Optic nerve transection
Rat
Retina

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10.1097/00001756-200011270-00057

Cite this

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title = "Up-regulated CNTF plays a protective role for retrograde degeneration in the axotomized rat retina",

abstract = "Using reverse transcription-polymerase chain reaction and in situ hybridization, we investigated the expression and cellular localization of ciliary neurotrophic factor receptor α (CNTFRα) in the rat retina following optic nerve transection (ONT). Following ONT, a signal for CNTFRα mRNA appeared in a layer-specific and time-dependent manner. In the ganglion cell layer, the signal showed a peak value I day after ONT, and then gradually decreased. In the inner nuclear layer the signal reached a peak value at 14 days of about 500\% of control level, but then decreased at 4 weeks. Our findings suggest that CNTF might play a protective role for the retrograde degeneration of retinal cells induced by ganglion cell death in the rat retina following ONT. (C) 2000 Lippincott Williams and Wilkins.",

keywords = "Ciliary neurotrophic factor receptor α, In situ hybridization, Optic nerve transection, Rat, Retina",

author = "Ju, \{Won Kyu\} and Kim, \{Keun Young\} and Lee, \{Mun Yong\} and Hofmann, \{Hans Dieter\} and Matthias Kirsch and Cha, \{Jung Ho\} and Oh, \{Su Ja\} and Chun, \{Myung Hoon\}",

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T1 - Up-regulated CNTF plays a protective role for retrograde degeneration in the axotomized rat retina

AU - Ju, Won Kyu

AU - Kim, Keun Young

AU - Lee, Mun Yong

AU - Hofmann, Hans Dieter

AU - Kirsch, Matthias

AU - Cha, Jung Ho

AU - Oh, Su Ja

AU - Chun, Myung Hoon

PY - 2000/11/27

Y1 - 2000/11/27

N2 - Using reverse transcription-polymerase chain reaction and in situ hybridization, we investigated the expression and cellular localization of ciliary neurotrophic factor receptor α (CNTFRα) in the rat retina following optic nerve transection (ONT). Following ONT, a signal for CNTFRα mRNA appeared in a layer-specific and time-dependent manner. In the ganglion cell layer, the signal showed a peak value I day after ONT, and then gradually decreased. In the inner nuclear layer the signal reached a peak value at 14 days of about 500% of control level, but then decreased at 4 weeks. Our findings suggest that CNTF might play a protective role for the retrograde degeneration of retinal cells induced by ganglion cell death in the rat retina following ONT. (C) 2000 Lippincott Williams and Wilkins.

AB - Using reverse transcription-polymerase chain reaction and in situ hybridization, we investigated the expression and cellular localization of ciliary neurotrophic factor receptor α (CNTFRα) in the rat retina following optic nerve transection (ONT). Following ONT, a signal for CNTFRα mRNA appeared in a layer-specific and time-dependent manner. In the ganglion cell layer, the signal showed a peak value I day after ONT, and then gradually decreased. In the inner nuclear layer the signal reached a peak value at 14 days of about 500% of control level, but then decreased at 4 weeks. Our findings suggest that CNTF might play a protective role for the retrograde degeneration of retinal cells induced by ganglion cell death in the rat retina following ONT. (C) 2000 Lippincott Williams and Wilkins.

KW - Ciliary neurotrophic factor receptor α

KW - In situ hybridization

KW - Optic nerve transection

KW - Rat

KW - Retina

UR - https://www.scopus.com/pages/publications/0034722693

U2 - 10.1097/00001756-200011270-00057

DO - 10.1097/00001756-200011270-00057

M3 - Article

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AN - SCOPUS:0034722693

SN - 0959-4965

VL - 11

SP - 3893

EP - 3896

JO - NeuroReport

JF - NeuroReport

IS - 17

ER -

Up-regulated CNTF plays a protective role for retrograde degeneration in the axotomized rat retina

Abstract

Keywords

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