TY - JOUR
T1 - Value of Surveillance 18F-FDG PET/CT in Colorectal Cancer
T2 - Comparison with Conventional Imaging Studies
AU - Choi, Eun Kyoung
AU - Yoo, Ie Ryung
AU - Park, Hye Lim
AU - Choi, Hyun Su
AU - Han, Eun Ji
AU - Kim, Sung Hoon
AU - Chung, Soo Kyo
AU - O, Joo Hyun
PY - 2012/9
Y1 - 2012/9
N2 - Purpose: To assess the value of PET/CT for detecting local or distant recurrence in patients who undergo surgery for colorectal cancer (CRC) and to compare the accuracy of PET/CT to that of conventional imaging studies (CIS). Methods: Tumor surveillance PET/CT scans done between March 2005 and December 2009 of disease-free patients after surgery with or without adjuvant chemotherapy for CRC were retrospectively studied. CIS (serial enhanced CT from lung base to pelvis and plain chest radiograph) were performed within 1 month of PET/CT. We excluded patients with distant metastasis on initial staging, a known recurrent tumor, and a lack of follow-up imaging. The final diagnosis was based on at least 6 months of follow-up with colonoscopy, biopsy, and serial imaging studies in combination with carcinoembryonic antigen levels. Results: A total of 262 PET/CT scans of 245 patients were included. Local and distant recurrences were detected in 27 cases (10. 3%). On case-based analysis, the overall sensitivity, specificity, and accuracy were 100, 97. 0, and 97. 3% for PET/CT and 85. 1, 97. 0, and 95. 8% for CIS, respectively. On lesion-based analysis, PET/CT detected more lesions compared to CIS in local recurrence and lung metastasis. PET/CT and CIS detected the same number of lesions in abdominal lymph nodes, hepatic metastasis, and peritoneal carcinomatosis. PET/CT detected two more metachronous tumors than did CIS in the lung and thyroid gland. Conclusion: PET/CT detected more recurrences in patients who underwent surgery for CRC than did CIS and had the additional advantage of evaluating the entire body during a single scan.
AB - Purpose: To assess the value of PET/CT for detecting local or distant recurrence in patients who undergo surgery for colorectal cancer (CRC) and to compare the accuracy of PET/CT to that of conventional imaging studies (CIS). Methods: Tumor surveillance PET/CT scans done between March 2005 and December 2009 of disease-free patients after surgery with or without adjuvant chemotherapy for CRC were retrospectively studied. CIS (serial enhanced CT from lung base to pelvis and plain chest radiograph) were performed within 1 month of PET/CT. We excluded patients with distant metastasis on initial staging, a known recurrent tumor, and a lack of follow-up imaging. The final diagnosis was based on at least 6 months of follow-up with colonoscopy, biopsy, and serial imaging studies in combination with carcinoembryonic antigen levels. Results: A total of 262 PET/CT scans of 245 patients were included. Local and distant recurrences were detected in 27 cases (10. 3%). On case-based analysis, the overall sensitivity, specificity, and accuracy were 100, 97. 0, and 97. 3% for PET/CT and 85. 1, 97. 0, and 95. 8% for CIS, respectively. On lesion-based analysis, PET/CT detected more lesions compared to CIS in local recurrence and lung metastasis. PET/CT and CIS detected the same number of lesions in abdominal lymph nodes, hepatic metastasis, and peritoneal carcinomatosis. PET/CT detected two more metachronous tumors than did CIS in the lung and thyroid gland. Conclusion: PET/CT detected more recurrences in patients who underwent surgery for CRC than did CIS and had the additional advantage of evaluating the entire body during a single scan.
KW - Colorectal cancer
KW - PET/CT
KW - Surveillance
UR - https://www.scopus.com/pages/publications/84865753052
U2 - 10.1007/s13139-012-0145-9
DO - 10.1007/s13139-012-0145-9
M3 - Article
AN - SCOPUS:84865753052
SN - 1869-3474
VL - 46
SP - 189
EP - 195
JO - Nuclear Medicine and Molecular Imaging
JF - Nuclear Medicine and Molecular Imaging
IS - 3
ER -
