Visible light-curable methacrylated glycol chitosan hydrogel patches for prenatal closure of fetal myelomeningocele

Hyun Sun Ko, Dae Hyeok Yang, Ahyoung Kim, Jeong Ha Wie, Sae Hyun Kim, Gun Jae Jeong, Hoon Hyun, Jong Chul Shin, Heung Jae Chun

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

In this study, we prepared visible light-curable methacrylated glycol chitosan (MGC) hydrogel patches for the prenatal treatment of fetal myelomeningocele (MMC) and investigated their feasibility using a retinoic acid-induced fetal MMC rat model. 4, 5, and 6 w/v% of MGC were selected as candidate precursor solutions, and photo-cured for 20 s, because the resulting hydrogels were found to possess concentration dependent tunable mechanical properties and structural morphologies. Moreover, these materials exhibited no foreign body reactions with good adhesive properties in animal studies. The inflammation scoring assessment in vivo exhibited the absence of foreign body reactions in MGC hydrogel treated lesion. The complete epithelial coverage of MMC was made with using 6 w/v% MGC hydrogel followed by well-organized granulation along with noticeable decrease of abortion rate and wound size that highlight the therapeutic potential for the prenatal treatment of fetal MMC.

Original languageEnglish
Article number120620
JournalCarbohydrate Polymers
Volume311
DOIs
StatePublished - 1 Jul 2023

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2020R1A2C1007588 ) and the Ministry of Trade, Industry and Energy (MOTIE) (No. 20018324 , 20017645 , 20014222 , 20017939 , and 20004627 ) of Republic of Korea.

Publisher Copyright:
© 2023

Keywords

  • Fetal myelomeningocele
  • Fetal surgical technique
  • Methacrylated glycol chitosan
  • Prenatal treatment
  • Visible light curable hydrogel patch

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