Wide dissemination of OXA-type carbapenemases in clinical Acinetobacter spp. isolates from South Korea

Kyungwon Lee; Mi Na Kim; Tae Yeal Choi; Soung Eun Cho; Seungok Lee; Dong Hee Whang; Dongeun Yong; Yunsop Chong; Neil Woodford; David M. Livermore

doi:10.1016/j.ijantimicag.2008.10.009

Wide dissemination of OXA-type carbapenemases in clinical Acinetobacter spp. isolates from South Korea

Kyungwon Lee
, Mi Na Kim
, Tae Yeal Choi
, Soung Eun Cho
, Seungok Lee
, Dong Hee Whang
, Dongeun Yong
, Yunsop Chong
, Neil Woodford
, David M. Livermore

Department of Laboratory Medicine

Yonsei University
University of Ulsan
Hanyang University
Ewha Womans University
Inje University
UK Health Security Agency

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

Carbapenem-resistant Acinetobacter spp. are being increasingly reported worldwide, including in South Korea, where we examined 144 representative isolates collected in a nationwide hospital survey in 2005. Metallo-β-lactamases were detected in only 19.4% of isolates, none of which were Acinetobacter baumannii, whereas 74.3% of isolates (mostly A. baumannii) expressed bla_OXA carbapenemase genes. Among the latter, 47 had bla_OXA-23-like genes and 56 had upregulated bla_OXA-51-like variants, including bla_OXA-66, _-83, _-109 and _-115; bla_OXA-115 was a novel variant, detected in two isolates. bla_OXA-72 (bla_OXA-40-like) was detected in only a single Acinetobacter baylyi isolate, whilst three Acinetobacter calcoaceticus isolates had both bla_VIM-2-like and bla_OXA-58 genes. Pulsed-field gel electrophoresis (PFGE) suggested the spread of A. baumannii clones with OXA carbapenemases within and between hospitals. In conclusion, the recent increase in imipenem-resistant Acinetobacter spp. from South Korea is mostly due to OXA-type carbapenemases.

Original language	English
Pages (from-to)	520-524
Number of pages	5
Journal	International Journal of Antimicrobial Agents
Volume	33
Issue number	6
DOIs	https://doi.org/10.1016/j.ijantimicag.2008.10.009
State	Published - Jun 2009

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Acinetobacter spp.
IMP-1
OXA carbapenemase
SIM-1
South Korea
VIM-2

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10.1016/j.ijantimicag.2008.10.009

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title = "Wide dissemination of OXA-type carbapenemases in clinical Acinetobacter spp. isolates from South Korea",

abstract = "Carbapenem-resistant Acinetobacter spp. are being increasingly reported worldwide, including in South Korea, where we examined 144 representative isolates collected in a nationwide hospital survey in 2005. Metallo-β-lactamases were detected in only 19.4\% of isolates, none of which were Acinetobacter baumannii, whereas 74.3\% of isolates (mostly A. baumannii) expressed blaOXA carbapenemase genes. Among the latter, 47 had blaOXA-23-like genes and 56 had upregulated blaOXA-51-like variants, including blaOXA-66, -83, -109 and -115; blaOXA-115 was a novel variant, detected in two isolates. blaOXA-72 (blaOXA-40-like) was detected in only a single Acinetobacter baylyi isolate, whilst three Acinetobacter calcoaceticus isolates had both blaVIM-2-like and blaOXA-58 genes. Pulsed-field gel electrophoresis (PFGE) suggested the spread of A. baumannii clones with OXA carbapenemases within and between hospitals. In conclusion, the recent increase in imipenem-resistant Acinetobacter spp. from South Korea is mostly due to OXA-type carbapenemases.",

keywords = "Acinetobacter spp., IMP-1, OXA carbapenemase, SIM-1, South Korea, VIM-2",

author = "Kyungwon Lee and Kim, \{Mi Na\} and Choi, \{Tae Yeal\} and Cho, \{Soung Eun\} and Seungok Lee and Whang, \{Dong Hee\} and Dongeun Yong and Yunsop Chong and Neil Woodford and Livermore, \{David M.\}",

year = "2009",

month = jun,

doi = "10.1016/j.ijantimicag.2008.10.009",

language = "English",

volume = "33",

pages = "520--524",

journal = "International Journal of Antimicrobial Agents",

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}

TY - JOUR

T1 - Wide dissemination of OXA-type carbapenemases in clinical Acinetobacter spp. isolates from South Korea

AU - Lee, Kyungwon

AU - Kim, Mi Na

AU - Choi, Tae Yeal

AU - Cho, Soung Eun

AU - Lee, Seungok

AU - Whang, Dong Hee

AU - Yong, Dongeun

AU - Chong, Yunsop

AU - Woodford, Neil

AU - Livermore, David M.

PY - 2009/6

Y1 - 2009/6

N2 - Carbapenem-resistant Acinetobacter spp. are being increasingly reported worldwide, including in South Korea, where we examined 144 representative isolates collected in a nationwide hospital survey in 2005. Metallo-β-lactamases were detected in only 19.4% of isolates, none of which were Acinetobacter baumannii, whereas 74.3% of isolates (mostly A. baumannii) expressed blaOXA carbapenemase genes. Among the latter, 47 had blaOXA-23-like genes and 56 had upregulated blaOXA-51-like variants, including blaOXA-66, -83, -109 and -115; blaOXA-115 was a novel variant, detected in two isolates. blaOXA-72 (blaOXA-40-like) was detected in only a single Acinetobacter baylyi isolate, whilst three Acinetobacter calcoaceticus isolates had both blaVIM-2-like and blaOXA-58 genes. Pulsed-field gel electrophoresis (PFGE) suggested the spread of A. baumannii clones with OXA carbapenemases within and between hospitals. In conclusion, the recent increase in imipenem-resistant Acinetobacter spp. from South Korea is mostly due to OXA-type carbapenemases.

AB - Carbapenem-resistant Acinetobacter spp. are being increasingly reported worldwide, including in South Korea, where we examined 144 representative isolates collected in a nationwide hospital survey in 2005. Metallo-β-lactamases were detected in only 19.4% of isolates, none of which were Acinetobacter baumannii, whereas 74.3% of isolates (mostly A. baumannii) expressed blaOXA carbapenemase genes. Among the latter, 47 had blaOXA-23-like genes and 56 had upregulated blaOXA-51-like variants, including blaOXA-66, -83, -109 and -115; blaOXA-115 was a novel variant, detected in two isolates. blaOXA-72 (blaOXA-40-like) was detected in only a single Acinetobacter baylyi isolate, whilst three Acinetobacter calcoaceticus isolates had both blaVIM-2-like and blaOXA-58 genes. Pulsed-field gel electrophoresis (PFGE) suggested the spread of A. baumannii clones with OXA carbapenemases within and between hospitals. In conclusion, the recent increase in imipenem-resistant Acinetobacter spp. from South Korea is mostly due to OXA-type carbapenemases.

KW - Acinetobacter spp.

KW - IMP-1

KW - OXA carbapenemase

KW - SIM-1

KW - South Korea

KW - VIM-2

UR - https://www.scopus.com/pages/publications/64549155641

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VL - 33

SP - 520

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JO - International Journal of Antimicrobial Agents

JF - International Journal of Antimicrobial Agents

IS - 6

ER -

Wide dissemination of OXA-type carbapenemases in clinical Acinetobacter spp. isolates from South Korea

Abstract

UN SDGs

Keywords

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